The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics (Google eBook)
A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.
What people are saying - Write a review
We haven't found any reviews in the usual places.
5-HT neurons 5-HT1A receptor 5-ht6 receptor antagonists 5-hydroxytryptamine Acad Sci USA adenylate cyclase affinity antibodies autoradiographic autoreceptors axon behavior Biol Chem Brain Res C-terminal Ca2+ cells cloning clozapine coupling cyclase dendrites desensitization disorders distribution domain dopamine dorsal raphe drugs effects efficacy expression fenfluramine fluoxetine functional G protein genetic GPCRs hippocampus human brain human serotonin increased inhibition interaction intracellular isoforms knockout mice ligands loop mediated membrane modulation Mol Pharmacol Molecular mouse mRNA mutations Natl Acad Sci Neurochem Neuropharmacology Neurosci novel palmitoylation pathway Pharmacol Exp Ther pharmacological phenotype phosphorylation polymorphism postsynaptic prefrontal cortex Proc Natl Acad protein–coupled radioligand raphe nucleus rat brain recep receptor activation receptor agonists receptor antagonist receptor gene receptor mRNA receptor subtypes regions regulation residues response rhodopsin RNA editing role Roth BL schizophrenia selective sequence serotonergic serotonin receptor signaling specific splice variants stimulation structure studies subunit suggest synaptic target tryptamine vivo