Opioid Analgesics in the Management of Clinical PainKathleen M. Foley, Charles E. Inturrisi |
Contents
Introduction | 1 |
Clinical Analgesic Studies and Sources of Variation in Analgesic | 13 |
Oral Morphine Kinetics | 25 |
Copyright | |
47 other sections not shown
Common terms and phrases
activity administration analgesia analgesic analgesic effect appear approximately assay binding blood buprenorphine cancer patients changes chronic pain clearance Clin clinical compared comparison concentration continuous curve DADL dependence depression determined disposition distribution dose drug duration edited elimination epidural estimate experience Foley function given half-life heroin higher humans important increase indicated individual infusion injection intensity intramuscular intrathecal intravenous Inturrisi kinetics less levels liver lower mean measured Medical meperidine metabolites methadone method morphine narcotic normeperidine observed obtained occur opiate opioid oral pain relief parenteral peak pentazocine period pharmacokinetic Pharmacol pharmacological plasma plasma concentration plasma levels postoperative pain potency present produce range ratio received receptor relationship relative renal reported Research respiratory response route samples scores severe shown shows side effects significant similar spinal studies subjects suggested systemic Table Ther tolerance treatment values York