Clinical Trials in the Rheumatic Diseases: A Selected Critical Review |
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active acute agents allowed analgesic analysis ankylosing spondylitis anti-inflammatory Arthr Rheum aspirin assessment azathioprine baseline benorylate better than placebo blind chloroquine clinical trials Colchicine Comments compared comparison continued controlled trial count criteria Curr cyclophosphamide D-penicillamine D/K compliance DB crossover demonstrated Design Diclofenac difference disease dose Double-blind double-blind crossover dropouts drugs efficacy et al evaluation Fenoprofen flurbiprofen followed given gold ibuprofen improvement indomethacin joint juvenile rheumatoid arthritis Ketoprofen levels measures ment mg daily mg/day months morning stiffness naproxen noted observers occurred osteoarthritis outcome pain parallel Patient preference period phenylbutazone Piroxicam placebo prednisone pseudogout randomized received reduced regimen reported response Rheumatol salicylate serum severe showed side effects significant difference significantly better Sodium statistical sulindac superior to placebo Suppl systemic lupus erythematosus Table Therapeutic Effect therapy tion Tolmetin treat treatment treatment of rheumatoid washout period weeks