Handbook of mucosal immunology
Researchers have recently made tremendous progress in the area of mucosal immunology, greatly increasing our understanding of the common mucosal immune system, mucosal infections, and oral immunization. However, thisresearch has not previously been made available in a single work. In its large 81/2"x 11"format, Handbook of Mucosal Immunology covers the entire spectrum of mucosal immunity and is organized in two main sections to present the basic biology of the common mucosal immune system and the immune responses of the mucosae. The first section provides an introduction and historical perspective of the mucosal immune system and includes comprehensive discussion of the development and physiology of mucosal defense. It discusses such topics as the structure and function of themucosal epithelium, characteristics of mucosal-associated lymphoid tissue (MALT), Peyers patches, and concepts of mucosal vaccines. The second section focuses on the secretory immune system with special reference to mucosal diseases in the digestive (GALT), respiratory (BALT), and genitourinary tracts. This information is especially important in light of the current interest in the mechanisms, transmission, and prevention of infectious diseases such as AIDS, hepatitis, and tuberculosis. Virtually all chapters have been authored by the original investigators responsible for key observations on which current concepts are based. This handbook will be an invaluable resource for a diverse group of both researchers and practicing clinicians.Molecular biologists, immunologists, veterinarians, public health workers, physicians in specialties from pediatrics to pulmonology, and graduate students of mucosal immunology will all find this handbook the most complete work on the subject.
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An Overview of
Cellular and Molecular Basis for Antigen
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acid activity adjuvant antibody response antigen apical B-cell bacteria basolateral Bienenstock binding Brandtzaeg CD8+ Cebra chain cholera toxin Clin clones cytokines cytotoxic effect endosomes enterocytes enzymes epithelial cells epithelium Escherichia coli expression factors function gastrointestinal gene germinal center glands glycoproteins helper T cells human IELs IgA antibodies IgA plasma cells IgA responses IgA2 IgAl immu immune response immune system immunoglobulin Immunol Immunology induced infection influenza inhibition interactions interleukin intraepithelial isotype lactoferrin lamina propria lymph nodes lymphocytes lymphoid tissue lysozyme macrophages mast cells McGhee mechanism mediated membrane Mestecky mice molecular molecules mouse mucosal mucosal immune mucosal surfaces murine Neutra oral tolerance peptide Peyer's patches pIgA plasma cells production protein rabbit receptor respiratory role salivary secretions secretory component secretory IgA serum SIgA small intestine specific stimulation structure studies switch differentiation Th2 cells tion tract transport uptake vaccine vesicles virus vitro vivo