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alloantibody alloantigens allogeneic allografts animals anti anti-idiotypic anti-TNP antibody antibody response antigen antigen-specific Asherson assay BALB/c cell activation cell populations cell response cell-mediated cellular clonal clones ConA contact sensitivity costimulator CTL-P culture cyclophosphamide cytotoxic T cells determinants DNFB donor dose effect effector cells experiments factor Figure FITC function graft hapten hapten-specific helper cells histocompatibility hypersensitivity IgG2 immune response immunogenic Immunol immunological induced inhibition injected interaction irradiated kidney killer cells lectin lymph node lymph node cells lymphocytes lymphoid cells lymphokine macrophages mechanism mediated membrane mice mitogenic molecules mouse murine normal nude opsonization precursors pretreatment production proliferation reaction reactive recipients renal allograft role SC-FITC serum soluble specific spleen cells SRBC stimulator cells studies supernatants suppression suppressor cells suppressor factor syngeneic T-cell Table target cells TCGF thymocytes thymus TNBS TNP-MRC tolerance tolerogen transplantation Ts-aff tumor unresponsiveness vitro vivo Voisin