Organocopper Reagents: A Practical ApproachRichard J. K. Taylor A laboratory manual detailing the procedures for the preparation and application of a group of highly specific reagents, and how to overcome the many problems associated with their use. Also includes a historical overview of organocopper chemistry; a description of starting material purification; and guidelines to the reaction, which are usually characterized by a high chemo-, regio-, and stereoselectivity. Begins a series providing practical and accessible laboratory guides for new and experienced researchers unfamiliar with the particular area. Annotation copyright by Book News, Inc., Portland, OR |
Contents
starting materials | 27 |
Higher order cyanocuprates | 37 |
Preparation of organocopper reagents using | 73 |
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50 mmol acetylene acid Aldrich Alexakis alkyl alkyne allylic anhydrous argon brine bromide cannula Caution Chapter Chem chemical-resistant safety goggles chiral chromatography conjugate addition cooling bath copper copper(I cryocool CuBr CuCN cuprate described in Protocol dropping funnel dropwise dry ether dry ice-acetone bath dry THF electrophiles enolate enone Equipment ester Flame dry flammable flask 250 mL freshly distilled gas inlet gloves and chemical-resistant Grignard reagents halide hexane HMPA inert gas iodide irritant flammable latex gloves ligand Lipshutz lithium magnetic stirring bar methyl methyllithium mmol moisture sensitive flammable n-Butyllithium needle nitrogen Normant organocopper organocopper reagents organometallic prepared procedures react reaction mixture reactivity room temperature round-bottomed flask round-bottomed flask 250 septum silyl solution Sonogashira stir the mixture stirring bar stopcock substrates supply and inlet Synth Synthesis syringe Tetrahedron Lett three-necked vinyl or latex vinylcopper wear disposable vinyl well-ventilated hood yield