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5-HT3 receptor Acad Sci acid activity acute addiction adenylyl cyclase agonists alcohol abuse Alcohol Clin Exp alcohol consumption alcohol dependence alcohol drinking alcohol intake alcohol preference alcohol withdrawal alcohol-seeking alterations anesthetic animal models anxiolytic behavioral benzodiazepine binding Brain Res buspirone cells chronic ethanol exposure chronic ethanol treatment Clin Exp Res clinical concentrations decrease dexfenfluramine dihydropyridine disorders disulfiram dizocilpine dopamine doses drugs effects of alcohol effects of ethanol ethanol administration ethanol consumption ethanol intake ethanol tolerance ethanol withdrawal ethanol-induced fluoxetine GABA GABAA receptor gene genetic glutamate glycine Harris RA hippocampal Hoffman PL hormone increase interaction levels lipid mechanism mice morphine naloxone naltrexone Neurochem neurohormones neurons neurotransmitter ondansetron opiate opioid Pharmacol Biochem Behav Pharmacol Exp Ther pharmacological physical dependence Psychiatry Psychopharmacology rat brain receptor antagonists reduced reinforcing release reported response role Samson self-administration sensitivity serotonin stimulation studies subunit symptoms synaptosomes Tabakoff type channels voltage-dependent calcium channels withdrawal seizures