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abortion acid acrocentric agents anencephaly aneuploidy assay associated atresia autosomal Barr bodies bilateral biochemical BIRTH DEFECTS bone born cells child chromo chromosomal abnormality cleft palate Clin clinical confirmed CONGENITAL MALFORMATIONS deficiency deformities Dept discussed disease dominant dose Down's syndrome drugs effect embryos evidence factors female fetal FOUNDATION-MARCH OF DIMES frequency gene genetic gestation Gynec heritable Hosp hydrocephalus incidence increased infants infection inheritance Inst involved karyotype latter limb literature male MARCH OF DIMES mechanism meclizine medication mental retardation metabolic mice minute reel mongolism mongoloid months mosaicism mothers multiple mutation NATIONAL FOUNDATION NATIONAL FOUNDATION-MARCH neonatal newborns NF-MOD normal Obstet offspring parents patients Pediat pedigree phenotypic phenylalanine phenylketonuria phocomelia pregnancy presented protein recessive references reported Selected Articles serum sex chromatin sex chromosome sibs spina bifida studies suggests synthesis teratogenic thalidomide tion tissue translocation trimester trisomy types Univ