Alzheimer's disease: from basic research to clinical applications / H.-J. Gertz and Th. Arendt (eds.).
H.-J. Gertz, Th Arendt
Springer, 1998 - Medical - 315 pages
As human longevity continues to be extended, so will the impact of age-associated dementia on individual lives and society. Alzheimera (TM)s disease as the most common cause of dementia in the elderly remains a sentinal problem and its underlying pathology is still poorly understood. Available therapeutic strategies require considerable refinement and the development of new therapeutic strategies need input from basic research. Thus continued efforts are necessary both to understand basic mechanisms of the condition and to achieve more powerfull therapies. This volume brings together the reports of basic scientists and clinical investigators. The chapters provide a spectrum of information valuable for clinicians and scientists. This issue bridges the gap between laboratory work in basic science and the development of urgently needed therapeutic strategies. Areas presented are the molecular and cellular biology of the disease, pathogenetic mechanisms and potential therapeutic targets, genetics, risk factors, strategies of prevention and treatment as well as practical aspects of medical and social care for patients with Alzheimera (TM)s disease.
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the size of the problem clinical manifestation
Alzheimers disease the size of the problem clinical manifestation
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3-amyloid Acad Sci activity Alzheimer disease Alzheimer patients Alzheimer type Alzheimer's disease amyloid precursor protein antioxidant apolipoprotein apoptosis Arch Neurol assessment associated astrocytes atrophy basal forebrain baseline Braak Brain Res Ca2+ calcium cell death CERAD cerebral changes cholinergic clinical cognitive decline cognitive functioning controls corpus callosum correlation cortex cortical deficits demented diagnosis diagnostic criteria disorders drugs effects elderly Exp Neurol free radical gene Geriatr hippocampus idebenone increased intracellular Jellinger kinase lesions Lewy body lymphocytes McGeer membrane memory impairment metabolism microglia mild cognitive impairment MMSE molecular mRNA mutations myelin neocortical neuritic Neurobiol Aging Neurochem neurodegenerative neurofibrillary tangles Neurology neuronal neuropathological neuropsychological Neurosci neurotrophin nimodipine non-demented normal aging NSAIDs oxidative stress pathological Perry placebo plaques preclinical propentofylline Psychiatry receptor regions Reisberg risk factors scores selegiline senile dementia signal stage stroke tacrine treatment variable vascular dementia white matter