GABA outside the CNS
during the past few years increasing interest has been focused on the role of gamma-aminobutyric acid (GABA) outside the central nervous systems (CNS).Biochemical, pharmacological, histochemical, physiological approaches have all been employed to investigate the role of GABA in themammalian periphery. The International Symposium on Peripheral GABAergic Mechanism held in Rome, July 1990, was devoted to gather scientists from allover the world in order to summarize and sythesize their most recent results and conceptions on the significance of GABA outside the CNS. Written in a thought-provoking style, this proceedings volume is an overviewof the timely knowledge about GABA in the peripheral nervous system and in non-neuronal tissues. Chapters of the book provide many examples for the diverse functions of this amino acid in the periphery as neurotransmitter, hormone, humoral or even trophic factor from the autonomic ganglia to the endocrine stomach and pancreas, from the tubular epithelium of the kidney to the spermatozoa.
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The Role of GABA in the Peripheral Nervous System
K R Jessen
14 other sections not shown
3H]GABA 3H]muscimol ACh release activity adrenal medulla agonists amino acids antagonist Autoradiographic axons baclofen bicuculline binding sites Biochem Bowery NG eds Brain Res catecholamine cholinergic chromaffin cells depolarization effect of GABA endogenous GABA enteric nervous system enzyme Erdo SL excitatory function GABA GABA concentrations GABA levels GABA transaminase GABA uptake GABA-immunoreactive GABA-positive GABA-T GABAA and GABAB GABAB receptors GABAergic GABAergic mechanisms GABAergic neurons gamma-aminobutyric acid gland glial guinea guinea-pig guinea-pig ileum Hills JM ileum immunocytochemical Immunohistochemical inhibition inhibitory innervation islets isolated Jessen Joo F Kasa Kerr DIB liver mammalian periphery mediated membranes modulation motility muscimol myenteric neurons myenteric plexus Neurochem neurons Neurosci Lett neurotransmitter non-neuronal ovary oviduct pancreas peripheral tissues Pharmacol Physiol physiological preganglionic principal neurons putrescine rat superior cervical Raven receptor-mediated responses role secretion SIF cells smooth muscle somatostatin stimulation studies superior cervical ganglion sympathetic ganglia synaptic Tanaka Taniyama transmitter Wolff JR y-aminobutyric acid