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abnormal Acad activity allele amino acid anencephaly animals anomalies antibodies antigens antiserum associated autosomal baby biochemical Biol birth cell culture changes chick child chondrocytes chromo cleft palate clinical component congenital defects congenital malformations deficiency differentiation disease Dose drug effect embryo enzyme evidence factors female fetal Figure formation frequency function gene genetic genotype germ cells hemoglobin heterozygotes heterozygous histone human hybrid hypothesis immunological incidence induced involved isozymes karyotype Lancet male Maryland maternal mechanisms meiotic ment mesenchyme messenger RNA metabolic metaphase mice molecular molecules mongolism mosaic mother mouse mutation Natl normal observed occur oocyte parents patient phenotype polypeptide population possible pregnancy present problem Proc produce protein rabbit relatively result serum sex chromatin sex chromosome somites specific structure studies suggested syndrome synthesis teratogenic thalidomide thymus tion tissue transferrin translocation trisomy variation vitro X chromosome York