Cerebral ischemia and dementia
In contrast to dementia of the Alzheimer type, the subject of dementia subsequent to cerebral ischemia has been discussed rather rarely. Now this book provides a summary of the brain morphology, neurochemistry and clinical aspects of dementia subsequent to cerebral ischemia. The contributions discuss the similarities and differences between the two predominant dementia types. The broad range of aspects cover 1) the morphology and morphobiology of brain tissue during aging and under the two pathological condi- tions, 2) the neuropathochemistry of post mortem brain tissue of patients as well as brain tissue from experimental animals, 3) CSF changes during aging and in dementia states and 4) clinical research, mainly using brain imaging tech- niques to differentiate between dementia types and to find a basis for rational therapeutic approaches.
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How Does Cerebrovascular Disease Cause Dementia?
The Epidemiology of Vascular Dementia
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abnormalities acid activity acute Alzheimer type Alzheimer's disease analysis Ann Neurol aphasia Arch Neurol areas assessment atherosclerosis atrophy axotomy basal Berlin Heidelberg bilateral Binswanger's disease Blood Flow Metab brain carotid artery cell cerebral blood flow cerebral cortex cerebral ischemia cerebrovascular disease changes cholinergic cholinergic neurons clinical cognitive computed tomography controls correlation cortical criteria damage deficits demented diagnosis disorders effects elderly focal forebrain function glucose glutamate Hachinski VC hemisphere hippocampus Hoyer hydrocephalus hypertension impairment increase ischemic stroke Kusehinsky lacunar lesions leukoaraiosis magnetic resonance imaging metabolism multi-infarct dementia neurological neurons neuropathological neuropsychological Neurosurg NMDA normal normal pressure hydrocephalus nucleus parietal pathological patients pentoxifylline perfusion periventricular plaque positron emission tomography postischemic prevalence protein rCBF receptor reduced regional cerebral risk factors Sabeluzole scans score severe significant subcortical symptoms Table thalamic tissue vascular dementia volume white matter white-matter