Na/K-ATPase and Related Transport ATPases: Structure, Mechanism, and RegulationL. Beaugé, David C. Gadsby, Patricio J. Garrahan This volume disseminates the most recent advances in understanding of the molecular structure, transport mechanism, and regulatory properties of the sodium/potassium adenosine triphosphatase. Recent knowledge gained from other transport ATPases is incorporated as well. The volume also provides contributions from crystallographers, cryoelectronmicroscopists, biochemists, cell biologists, biophysicists, physiologists, and pharmacologists. |
Contents
TwoDimensional Crystal Formation from Solubilized Membrane Proteins | 9 |
Oligomeric Structure of Solubilized Na+K+ATPase Linked to E₁E2 | 19 |
Organization of the Membrane Domain of the NaKPump By STEVEN J D | 30 |
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3H]ouabain Acta amino acids antibodies assay ATP binding ATPase ATPase activity binding sites Biochem Biochemistry Biol Biophys Ca-ATPase Ca2+ pump Ca2+-ATPase calmodulin cardiac cardiac glycosides catalytic cation cells charge movements Chem components concentration containing COOH-terminal curves cytoplasmic decrease dependence detergent dissociation domain e-mail effect electrogenic endogenous enzyme eosin equilibrium experiments expression extracellular FIGURE FITC fluorescence function gene H,K-ATPase inactivation increase inhibition interaction isoforms KARLISH kidney kinase kinetics labeled ligands LINGREL loop measured Mg2+ molecular mutant myocytes Na,K Na,K-ATPase Na,K-ATPase activity Na,K-pump NaCl nucleotide observed obtained occlusion oligomycin omeprazole oocytes ouabain P-type ATPases pantoprazole phosphoenzyme phosphorylation Physiol plasma membrane presence protein purified rate constants reaction region release residues sarcoplasmic reticulum sequence shown sodium pump solubilized specific steady-state structure studies subunit translocation transmembrane segments transport uptake voltage wild-type yeast