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accrue applied research basic discovery basic scientific research benefits 2(f benefits arising benefits associated benefits of scientific changes in expenditure changes in research consequential costs and benefits Council for Scientific curiosity-oriented research deduce Department of Education discount rate discounted cash flow Discounted cost discoveries associated discovery arising economic value Education and Science effect of notional estimate ex post studies example exploitation further discounted give rise given field growth rate Harry Johnson ideas important increase information transfer laboratories major discoveries major scientific discoveries method Nationalised Industries notional change notional delays notional marginal changes nuclear power industry paper paragraph parameters pn junctions pool of knowledge present value research expenditure result science and technology science-based industries scientific activity Scientific Policy specific studies proposed suggest technique total economic benefit U.K. expenditure U.K. industrial underlying scientific discoveries United Kingdom University unpredictably Washington D.C. weighted mean whole world industry