The Stereoselectivity and Pharmacokinetics of D, 1-carnitine in the Dog |
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Page 1
... acetyl- transferase ( 8,9 ) . Fritz and Schultz ( 10 ) demonstrated CH3 1+ CH3 - N - CH2 - CH - CH2 - COOH CH2 OH ( I ) that only the 1 - isomer of carnitine is active in the ability to transfer acyl groups across the myocardial ...
... acetyl- transferase ( 8,9 ) . Fritz and Schultz ( 10 ) demonstrated CH3 1+ CH3 - N - CH2 - CH - CH2 - COOH CH2 OH ( I ) that only the 1 - isomer of carnitine is active in the ability to transfer acyl groups across the myocardial ...
Page 5
... acetyl- coenzyme A ( lithium salt , approximately 70 % pure ) , Þ 50 ul of 10 uci ( 14c ) -acetyl coenzyme A ( 85,000-90,000 CPM ) , C 50 ul of the plasma sample , and 25 ul of .49 U carnitine acetyltransferase . The reaction is ...
... acetyl- coenzyme A ( lithium salt , approximately 70 % pure ) , Þ 50 ul of 10 uci ( 14c ) -acetyl coenzyme A ( 85,000-90,000 CPM ) , C 50 ul of the plasma sample , and 25 ul of .49 U carnitine acetyltransferase . The reaction is ...
Page 6
Robert J. Wills. l - carnitine + ( 14C ) -acetyl - CoA DTNB ( 14c ) Acetyl carnitine carnitine acetyltransferase + COASH Eq . 1 Eleven standards were included with each assay and all plasma samples were assayed in triplicate . Each tube ...
Robert J. Wills. l - carnitine + ( 14C ) -acetyl - CoA DTNB ( 14c ) Acetyl carnitine carnitine acetyltransferase + COASH Eq . 1 Eleven standards were included with each assay and all plasma samples were assayed in triplicate . Each tube ...
Common terms and phrases
0-L DOG KJ 1-Carnitine to Dog 1118 digital computer ACADEMIC COMPUTING CENTER ANALYSIS OF VARIANCE ANOVA assay AUCO BLANK BLANKSCOMMON bolus intravenous injection CARNITINE CONC CENTER PROGRAM NWAY computer equation COMPUTING CENTER CARNITINE COMPUTING CENTER PROGRAM Concentration mcg/ml concentration of drug Concentration of l-carnitine CONTROL CARDS counts per minute DOGA DOGC drug in plasma ENTRY IS MEAN F-RATIO following a bolus FORTRAN-MACC GSPCIL ICGCIL IMAX Injection of 1-Carnitine Injection of 80 INPUT RECORD ITEMS ITERATION L-CARNITINE AUC ANALYSIS l-carnitine in plasma LISTING OF CONTROL MADISON ACADEMIC COMPUTING mg of l-carnitine myocardial infarct NEXP NEXP1 NREG NROBS NUMBER ORDER FACTOR OUTPUT FOR VARIABLES p-value Paired t-Test Pharmacokinetic Parameters PIVOT REDUCTION Plasma After Intravenous plasma samples plasma versus racemic rate constants RUNAR SCOMMON SECOND IS FREQUENCY sling SUBROUTINE SUM OF SQUARES TRANT TRMNT two-compartment model V₁ VALUE VARIANCE AUC versus time following