This volume will focus on and emphasise the clinical relevance of diabetic nephropathy, a relatively common problem of diabetes. It affects about one in three patients with Type 1 diabetes, and left untreated can lead to a progressive decline in renal function, accompanied by retinopathy and arterial hypertension, which, in turn, leads to cardiovascular disease - a common cause of death in these patients. Diabetic Nephropathy will also provide the reader with a solid grounding in current basic and clinical research.
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Natural Course of Diabetic Nephropathy
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abnormalities ACE inhibitors albumin albumin excretion rate albuminuria angiotensin antihypertensive antihypertensive therapy associated basement membrane blood pressure capillary cardiovascular cholesterol Clin clinical collagen complications coronary heart disease creatinine clearance decrease dependent diabetes diabetic nephropathy diabetic patients diabetic rats diagnosis dialysis effect elevated enalapril endstage renal failure Engl follow-up gene genetic glomerular filtration rate glomeruli glucose glycaemic control glycation Hasslacher HbAic HSPG hyperfiltration IDDM patients impaired incidence incipient increased insulin kidney Kidney Int lesions levels lipid lipoprotein matrix mesangial cells metabolic control microalbuminuria mmHg Mogensen mortality nephropathy in type NIDDM non-diabetic non-insulin-dependent normal normotensive overt nephropathy patients with diabetic patients with type plasma pregnancy prevalence prognosis progression of diabetic protein intake proteinuria proteoglycan reduced renal disease renal failure renal function renal insufficiency renal replacement therapy risk factors serum Study Group systolic transplantation trial triglyceride type 2 diabetes urinary albumin excretion urine vascular