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antibodies antigen antithrombotic aprotinin aPTT arterial aspirin assay binding bleeding blood calcium clinical clotting coagulation collagen compared complex concentration correlation decreased Dept domain dose effect ELISA endothelial cells evaluated factor VII factor Xa fibrin fibrinogen fibrinolytic fibronectin fragment Fragmin function FVIII Hematology Hemostasis heparin hirudin Hospital human HUVEC increased incubated induced infusion inhibition inhibitor injection interaction Laboratory levels LMWH low molecular weight measured Medicine membrane mg/kg molecular weight heparin monoclonal monoclonal antibody mRNA ng/ml normal observed oral anticoagulants patients peptide plasma plasmin plasminogen activator platelet platelet activation platelet adhesion platelet aggregation presence protein prothrombin rabbit receptor recombinant samples sequence significantly specific substrate surface surgery t-PA TFPI therapy thrombin thromboembolism thrombomodulin thromboplastin thrombosis thrombotic thrombus thrombus formation tissue factor treatment tumor u-PA U/ml University vascular vein venous vitro vivo warfarin