This textbook for medical and science students emphasises the mechanisms by which drugs act and relates these to pharmacological effects and clinical uses. It sets out for the reader a route from a molecular understanding of receptors and drug actions, to the uses of groups of drugs.
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Method and measurement in pharmacology
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acetylcholine action potential activity adrenoceptor agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain calcium cancer cardiac cause cells chemical cholinergic clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene given glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous involved ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary platelet produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissue toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular vitamin
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International Review of Cytology, Volume 208
Limited preview - 2001