PharmacologyThe aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
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Page 340
... depression which is caused by drug overdose ( see below ) . DRUGS CAUSING RESPIRATORY DEPRESSION Many drugs which have a depressant action on the cen- tral nervous system cause a greater or lesser degree of respiratory depression ...
... depression which is caused by drug overdose ( see below ) . DRUGS CAUSING RESPIRATORY DEPRESSION Many drugs which have a depressant action on the cen- tral nervous system cause a greater or lesser degree of respiratory depression ...
Page 552
... depressed subjects have shown convincingly that the level is reduced in bipolar depressive patients , and is lower during the depressive than during the manic phase . In unipolar depression , however , MHPG excretion , though highly ...
... depressed subjects have shown convincingly that the level is reduced in bipolar depressive patients , and is lower during the depressive than during the manic phase . In unipolar depression , however , MHPG excretion , though highly ...
Page 553
... depression The monoamine theory , proposed in 1965 , suggests that depression results from functionally deficient monoaminergic ( noradrenaline and / or 5 - HT ) transmission in the CNS . The theory was based on the ability of known ...
... depression The monoamine theory , proposed in 1965 , suggests that depression results from functionally deficient monoaminergic ( noradrenaline and / or 5 - HT ) transmission in the CNS . The theory was based on the ability of known ...
Contents
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
Copyright | |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular