Antioxidants in Therapy and Preventive MedicineIngrid Emerit, Lester Packer, Christian Auclair Twenty years ago, the enzyme superoxide dismutase which uses the superoxide radical anion as its specific substrate was reported. With this discovery was born a new scientific field, in which oxygen, necessary for aerobi c 1 ife on thi s planet, had to be cons i dered also in terms of its toxicity and stresses. This stimulated the search for knowledge of active oxygen species in biology and medicine. Superoxide and other reactive oxygen species are now implicated in many disease processes. Major advances have been achieved during these past years with respect to free radical generation and mechanisms of free radical action in causing tissue injury. In parallel, the possibil ity of influencing free radical related disease processes by antioxidant treatment was studied in various in vitro and in vivo systems. This was the unique theme of a conference organized in Paris by the Society for Free Radical Research (December 9-10, 1988) which brought together experts from basic sciences and clinicians in order to evaluate the current status of antioxidant therapy. The conference emphasized fundamental processes in antioxidant action. Among the major topics were superoxide dismutase (SOD) and low molecular weight substances with such activity, called SOD mimics. Other antioxidant enzymes were also considered. Antioxidant vitamins, in particular vitamins E and C, other naturally occurri ng antioxidants and vari ous synthet i c antioxidants were included in the presentations as there is now a rapidly developing series of compounds with potentially interesting clinical applications. |
Contents
SUPEROXIDE DISMUTASE | 1 |
The Role of Superoxide Dismutase SOD in Preventing | 13 |
The Protective Role of Superoxide Dismutase During | 29 |
Copyright | |
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Antioxidants in Therapy and Preventive Medicine Ingrid Emerit,Lester Packer,Christian Auclair Limited preview - 2012 |
Antioxidants in Therapy and Preventive Medicine Ingrid Emerit,Lester Packer,Christian Auclair No preview available - 2012 |
Antioxidants in Therapy and Preventive Medicine Ingrid Emerit,Lester Packer,Christian Auclair No preview available - 2012 |
Common terms and phrases
activity adriamycin allopurinol anthralin antioxidant Antioxidants in Therapy arachidonic acid ascorbate assay autoxidation Biochem Biol biological Biophys blood catalase cells cellular chelators Chem Clin clinical complex compounds concentration Cu(II damage decreased deferoxamine deficiency disease dose drug Ebselen effect Emerit enzymes ferritin formation FRANCE free radical gastric mucosal glutathione peroxidase human hydrogen peroxide hydroperoxides hydroxyl radical increased incubation induced inflammatory inhibition inhibitors injury iron irradiation ischemia ischemia-reperfusion lens levels lipid peroxidation liver lung mechanism membrane metabolism metabolites mg/kg mice microsomes mitochondrial neutrophils nitroxides oxidative stress oxygen radicals oxygen species pancreatic patients plasma Plenum Press Preventive Medicine Edited production prostaglandin protection proteins radical scavengers rats reaction reactive redox reduced reductase reperfusion role selenium serum studies superoxide anion superoxide dismutase Therapy and Preventive tissue tocopherol toxicity treatment trimetazidine vitamin vitamin E vitro vivo xanthine oxidase