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Immunosuppression by Murine Leukemia Viruses
Restoration of Immunologic Competence in Viral Leukemogenesis
Does Immunity Promote or Inhibit Tumor Growth?
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animals anti antibody formation antibody precursor cells antibody response antigen APFC response APFCs autoimmune BALB/c BALB/c mice Ceglowski cell-mediated immunity challenge immunization chronic clinical coli LPS Cyclophosphamide cytotoxic deficiency depression develop donors dose et.al FLV infection FLV-infected mice function host humoral immunity immune complex immune response immune system immunodeficiency immunodepression immunogenicity Immunol immunologic immunopathology immunosuppression incidence induced infected cells infected mice infected with FLV inoculation interferon large numbers LCM virus leukemia leukemia virus leukemic lymph node lymphocytes lymphoid cells macrophages malignant mechanism mice infected mouse neutralizing antibody normal NZB/NZW mice oncogenic patients PFCs Proc produce protein reactivity recipients Reprinted with permission rI.rC role serum sheep RBC Sindbis virus specific spleen cells sponse statolon Steinberg stimulation studies suppression surface surveillance susceptibility thymectomy thymic thymocytes thymus tion titers transfer transplantation tumor vaccine viral antigens viral infections viremia virion virus-induced viruses vitro Zealand mice