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abnormal Amphibia appears area pellucida avian axial mesoderm Biol blasto blastocoel blastoderm blastopore blastula cells chick embryo chorda chorio-allantoic grafts coelom considerable defects derm described developmental differentiation discussed dorsal early ectoderm effect elongation embryo embryonic axis endoderm epiblast epidermis epigenetic evidence evocation experiments feather fore-brain fore-gut formation formed fowl fragments gastrulation gene genetic graft growth Hamburger head process host hypoblast incubation Induced neural influence injected insulin invagination isolated Landauer later stages layer Lillie limb bud localisation maps melanoblasts mid-line morphogenetic movements neural plate neural tissue neural tube node normal notochord occur optic organisation organs original papilla Pasteels pattern pigment placode polydactyly posterior region presumptive areas presumptive mesoderm primitive streak primitive streak stage produced Rawles regeneration removed rudiments Rudnick rumplessness seems showed side similar somites Spratt suggested surface tail bud transplanted types ventral vesicle vitro Wetzel whole Willier Wolff yolk