Advances in Enzymology and Related Areas of Molecular Biology, Volume 78 (Google eBook)

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Eric J. Toone
John Wiley & Sons, Oct 13, 2011 - Science - 500 pages
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This book covers important advances in enzymology, explaining the behavior of enzymes and how they can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary processes. Advances in Enzymology focuses on enzymes, the primary catalysts of life processes. The explanation of the behavior of enzymes can be found via studies of their chemical mechanisms and can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary processes. The transglutaminases, first described in 1957, are a large, widely-distributed family of enzymes canonically responsible for the amidation/transamidation of protein side chains. The extraordinary diversity of names associated with various enzymatic activities now recognized and aggregated as transglutaminase bears witness to the remarkable diversity of biological roles associated with the activity, including myriad human diseases.
  

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Contents

AND RELATED AREAS OF MOLECULAR BIOLOGY Structure and Regulation of Type 2 Transglutaminase in Relation to Its Physiological Functi...
1
AND RELATED AREAS OF MOLECULAR BIOLOGY Physiopathological Roles of Human Transglutaminase 2
47
AND RELATED AREAS OF MOLECULAR BIOLOGY Transglutaminase in Epidermis and Neurological Disease or What Makes a Good CrossLinki...
97
AND RELATED AREAS OF MOLECULAR BIOLOGY Transglutaminase 2 A New Paradigm for NF B Involvement in Disease
161
AND RELATED AREAS OF MOLECULAR BIOLOGY Transglutaminase 2 At the Crossroads between Cell Death and Survival
197
AND RELATED AREAS OF MOLECULAR BIOLOGY Tissue Transglutaminase and Its Role in Human Cancer Progression
247
AND RELATED AREAS OF MOLECULAR BIOLOGY Transglutaminase 2 Dysfunctions in the Development of Autoimmune Disorders Celiac Dise...
295
AND RELATED AREAS OF MOLECULAR BIOLOGY Effects and Analysis of Transglutamination on Protein Aggregation and Clearance in Neuro...
347
AND RELATED AREAS OF MOLECULAR BIOLOGY TransglutaminaseMediated Remodeling of the Human Erythrocyte Membrane Skeleton Rele...
385
AND RELATED AREAS OF MOLECULAR BIOLOGY Irreversible Inhibitors of Tissue Transglutaminase
415
AND RELATED AREAS OF MOLECULAR BIOLOGY Methionine Adenosyltransferase SAdenosylmethionine Synthetase
449
AND RELATED AREAS OF MOLECULAR BIOLOGY Index
523
AND RELATED AREAS OF MOLECULAR BIOLOGY Color Plate
549
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About the author (2011)

Eric J. Toone, PhD, is Professor of Chemistry and Professor of Biochemistry at Duke University. He holds numerous patents and has written extensively on physical organic and biophysical chemistry. Professor Toone has served as a member of the Bioorganic and Natural Products Study Section at the National Institutes of Health, and is currently a member of the NSERC Organic & Inorganic Review panel (Canada). Professor Toone is the Deputy Director for the Advanced Research Projects Agency—Energy (ARPA-E) of the Department of Energy and directs ARPA-E's electrofuels program.

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