Advances in Enzymology and Related Areas of Molecular Biology, Volume 78 (Google eBook)
Eric J. Toone
John Wiley & Sons, Oct 13, 2011 - Science - 500 pages
This book covers important advances in enzymology, explaining the behavior of enzymes and how they can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary processes. Advances in Enzymology focuses on enzymes, the primary catalysts of life processes. The explanation of the behavior of enzymes can be found via studies of their chemical mechanisms and can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary processes. The transglutaminases, first described in 1957, are a large, widely-distributed family of enzymes canonically responsible for the amidation/transamidation of protein side chains. The extraordinary diversity of names associated with various enzymatic activities now recognized and aggregated as transglutaminase bears witness to the remarkable diversity of biological roles associated with the activity, including myriad human diseases.
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Acad AdoMet aggregates Alzheimer’s disease amine amino acid antibodies apoptosis apoptotic apoptotic cells autoimmune autophagy binding Biochem Biophys brain Ca2+ cancer cells catalytic celiac disease Cell Biol cell death cellular Chem complex cross-linking cystamine cysteine deamidation differentiation dimer domain effects enzyme erythrocytes extracellular factor factor XIII Fesus fibronectin formation function gene gliadin gliadin peptides glutamine gluten human huntingtin Huntington’s disease identified Immunol increased induced inflammatory inhibition inhibitors integrin interaction involucrin involved keratinocytes kinase Lewy bodies liver Lorand lysine macrophages matrix mechanism Melino membrane methionine methionine adenosyltransferase mice molecular mouse mutations N-terminal Natl Neurochem neuronal NF-B activation nucleotide pathway patients peptides phagocytosis Piacentini polyglutamine polymers Proc promoter protein reaction reactive receptor regulation role S-adenosylmethionine sequence shown signaling structure studies substrate subunit synuclein TGase 2 expression TGase activity TGase-2 tissue transglutaminase transamidation activity transglutaminase activity tumor vitro vivo