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Mammalian Cell Mutagenesis by Polycyclic Aromatic
Factors Affecting Polycyclic HydrocarbonInduced Cell
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3-methylcholanthrene Acad acid Air Pollut airborne particulates Anal analysis anthracene arene oxides bay-region benz[a]anthracene binding Biochem Biol Biophys Cancer Res carcinogenesis carcinogenic carcinogenic activity cells Chem chemical chromatography chrysene cigarette smoke coal combustion compounds concentrations conjugates Conney covalent crude oils cytochrome P-450 derivatives dihydrodiols diol epoxides dose emissions Environ environmental enzyme extraction fluoranthene formation formed fraction fuel Gelboin hamster Health hemoprotein Hoffmann hydroxylase hydroxylation incubation induced isomers Jerina K-region Levin liquid liver microsomes lung membrane metabolic activation metabolites method mice microsomes mouse skin mutagenic NADPH naphthalene Natl nitrosamines oxygen PAH's particulate petroleum phenols polycyclic aromatic hydrocarbons polycyclic hydrocarbons polynuclear aromatic hydrocarbons Proc protein pyrene pyrolysis quinones radical rat liver reaction reactive metabolite reduced reductase reported samples Sawicki shale studies substrate synthesis Table tion tissue tobacco smoke tumor tumorigenic Wynder Yagi