Bone Marrow Failure SyndromesThis comprehensive and clear text familiarizes clinicians with the most recent information concerning bone marrow failure syndromes, including anemia, leukopenia, and thombocytopenia. Twelve top experts present state-of-the-art guidance on pathophysiology and treatment, with an emphasis on chemotherapy. The result is an indispensable source on the treatment of these often life-threatening diseases. |
Contents
Agranulocytosis 156 Neal S Young M D | 1 |
Thrombocytopenic Purpura 183 | 8 |
Fanconis Anemia 47 Stephen Rosenfeld M D | 47 |
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abnormalities acquired activity acute agents agranulocytosis analysis antibody aplastic anemia apoptosis appear associated Blood blood cell bone marrow transplantation cause chromosome chronic Clin clinical clonal clone colony common counts decreased defect deficiency develop diagnosis disease disorders donor doses drug early effects et al evidence expression factor Fanconi Fanconi anaemia function gene genetic granulocyte growth factor Haematol hematologic hematopoietic HSCs human immune immunosuppression improved increased induced infection inhibition initial Intern late less leukemia levels lymphocytes major marrow failure mechanism metaplasia mutations myelodysplastic syndromes myeloid neutropenia normal observed occurs paroxysmal nocturnal patients platelet present production protein pure red cell rare receptor red cell aplasia reported response result risk secondary serum severe aplastic specific stem cell suggested suppression syndrome Table therapy tion toxicity transfusion treated treatment trial usually virus vitro Young