Pharmacology of Opioid Peptides

Front Cover
L F Tseong
CRC Press, Sep 1, 1995 - Medical - 500 pages
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This book is being published at a time when opioid receptors have recently been cloned. The structural characteristics of opioid receptors and the recent advances in their molecular cloning and expression are explicated. Connecting these cloned opioid receptors with the pharmacology of opioid receptor actions is of particular importance. The use of antisense oligodeoxynucleotides to opioid receptors to elucidate the neural mechanisms of opioid action is detailed.
As analgesia is one of the most important clinical functions for opioids and opioid peptides, this book concentrates on the detailed mechanisms of action of opioids and opioid peptides for the production of analgesia. The significant pharmacologic actions of opioids and opioid peptides in gastrointestinal function, immune function, cardiovascular and respiratory regulation, addiction and the cellular mechanisms involved in tolerance and dependence of opioids are also described.
The book will be of interest both to researchers investigating the neural mechanisms of the pharmacologic and physiologic functions of the endogenous opioid system and to clinicians who are involved in pain management and assessment.
  

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Contents

Selective ligands for n and S opioid receptors
1
Bruce Nock
29
Molecular characterization of opioid receptors
57
Enzymes involved in opioid peptide biosynthesis
87
GProteins and opioid receptors functions
109
Cellular mechanisms of excitatory and inhibitory actions of opioids
131
Regulation of enkephalins and catecholamine synthesizing
151
Functional roles of opioids in the hippocampus
169
The effects of diabetes on opioidinduced antinociception
271
Opioid peptides opioid receptors and peripheral analgesia
287
Modulation of opioid receptors by antiopioid peptides
303
Nitrous oxide and endogenous opioid peptides
321
The role of opioid peptides in environmentallyinduced analgesia
345
Opioid peptides in gastrointestinal functions
397
The role of opioid peptides in immune function
411
Opioid peptides in cardiovascular and respiratory regulation
425

Regulation of enkephalin in glia
187
The modulation of nociception by enkephalincontaining
197
Pharmacological characterization of opioid 8 and K receptors
219
Mechanisms of endorphininduced antinociception
249
Endogenous opioids and addiction
445
Cellular mechanisms of opioid tolerance and dependence
463
INDEX
503
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