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4-aminopyridine acetylcholine receptors acetylcholine release action potential activity agonist alkaloids amplitude anaesthesia anaesthetic antagonist anticholinesterase anticholinesterase drugs atracurium axon axoplasm binding blocking drugs Bowman British Journal calcium channels cells choline cholinergic cholinesterase cholinoceptors clinical compounds concentration contractility contraction curare dantrolene decamethonium denervated depolarization depolarizing drugs depression dose duration of action edrophonium effect endplate potential enzyme etal extracellular Figure frequency frog gallamine inactivation increase inhibition injected innervated interaction ion channels Journal of Pharmacology Journal of Physiology K+ channels Marshall mechanism membrane potential mepps molecules motor endplate motor nerve muscarinic receptors muscle fibres neostigmine nerve endings nerve impulse nerve stimulation nerve terminals neuromuscular junction neuromuscular transmission neuromuscular-blocking drugs non-depolarizing onset pancuronium plasma postjunctional prejunctional protein release of acetylcholine repetitive firing response sarcoplasmic reticulum skeletal muscle sodium channels succinyldicholine synthesis tetanic tibialis anterior muscle toxin train-of-four transmitter release tubocurarine twitches vecuronium vesicles Waud Zaimis