Approaches to Gene Mapping in Complex Human Diseases

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Jonathan L. Haines, Margaret A. Pericak-Vance
Wiley, Oct 8, 1998 - Science - 464 pages
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Approaches to Gene Mapping in Complex Human Diseases

Edited by Jonathan L. Haines and Margaret A. Pericak-Vance

Recent years have seen a tremendous growth in statistical and laboratory methods for genetic mapping -a process by which we discover genes that contribute to heart disease, hypertension, diabetes, asthma, cancer, and other complex genetic disorders not controlled by a single gene.

Approaches to Gene Mapping in Complex Human Diseases is the first book devoted to the analysis of such common, inherited diseases. This text helps the reader sort through the plethora of available resources, choose the best methodology for a given problem, and design successful gene mapping projects from the ground up. In eighteen chapters, compiled by two of the leading figures in the field, this book covers a wide range of topics -from the process of selecting families to the testing of candidate genes. It provides indispensable information on:
* Genetic concepts and statistics pertaining to mapping genetic disease
* Issues involved in collecting and handling biological samples and data
* Strategies for generating data in the lab
* Methods of analysis such as Lod score, Sib-pair, or Affected Relative-Pair
* Public databases and mapping resources
* Sources of statistical and genetic information, software, and documentation.

Approaches to Gene Mapping in Complex Human Diseases clearly explains concepts and design procedures while keeping technical details to a minimum. For geneticists, clinicians, molecular biologists, epidemiologists, and anyone interested in the pursuit of genes, it provides a solid grounding in the fundamentals and facilitates a firm grasp of the most advanced procedures and techniques available.

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Contents

Disease Traits
1
Basic Concepts in Genetics
17
Defining Disease Phenotypes
53
Copyright

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About the author (1998)

JONATHAN L. HAINES is Director of the Program in Human Genetics, Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine. His research into the localization and identification of genes involved in human disease includes studying Alzheimer's disease, multiple sclerosis, Parkinson's disease, autism, macular degeneration, and other complex diseases.

MARGARET A. PERICAK-VANCE is Director of the Center for Human Genetics and Chief of the Section of Medical Genetics in the Department of Medicine, Duke University School of Medicine. She is a founding Fellow of the American College of Medical Genetics. Her research interests include the integration of genomic and statistical technologies and their application to diseases of importance to public health, with an emphasis on neurologic diseases.

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