Abnormalities of IgG glycosylation and immunological disorders
Glycobiology has become the focus of considerable research in recent years as the role of oligosaccharides in both health and disease has come under scrutiny. During this period particular emphasis has been placed on the glycosylation of human immunoglobulins, notably IgG, not least because clear links with a restricted range of human diseases has been established. Abnormalities of IgG Glycosylation and Immunological Disorders uniquely draws together the facts that have emerged to link abnormalities in IgG glycosylation and immunological disease, especially rheumatoid arthritis. It reviews all aspects of immunoglobulin glycosylation abnormalities, including the structural anatomy of glycoproteins; the methods used to analyse them; the clinical aspects of glycobiology in both human disease and animal models; the glycosylation enzymes and the genes that encode and regulate these enzymes; and the possible pathogenicity of IgG. The chapter authors have been chosen because of the original contributions they have made to this exciting field of research. As such this authoritative and well referenced volume will be indispensable to both clinicians and basic scientists with an interest in glycosylation, as well as rheumatologists, immunologists, bacteriologists and glycobiologists
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1,4-galactosyltransferase Abnormalities Acad Sci USA agalactosyl IgG analysis antigen Arthritis Rheum assay autoantibody B-cell biantennary binding Biochem Biol Chem Bodman KB carbohydrate cDNA cell lines cell surface cloning collagen contain correlation domain Dwek RA enzyme epitopes expression Figure fucose galactose galactosyltransferase gene glycans glycoproteins glycosylation glycosylation changes glycosyltransferases Golgi human IgG IgG galactosylation IgG glycoform IgG glycosylation IgG molecules IgG subclasses immunoglobulin infection interaction Isenberg lectins levels of agalactosyl lymphocytes Mana1-3 arm mannose mice Molecular monoclonal antibodies mouse murine IgG myeloma myeloma proteins N-acetylglucosamine N-linked oligosaccharides Natl Acad Sci normal oligomannose oligosaccharide chains oligosaccharides Parekh RB pathway patients with RA patients with rheumatoid pregnancy Proc Natl Acad protein RA patients Rademacher TW receptors reduced rheumatoid arthritis rheumatoid factor Rook GAW samples sequence sera serum IgG sialic acid sialylated specificity structures studies sugar chains synovial terminal GlcNAc transferase tumour