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acid Agriculture Ajinomoto amino acid application of rDNA basic research billion U.S. biological containment bioreactors biosensors Biotech biotechnology biotechnology companies budget Category 3 applications Center chemicals collaboration Corporation decontaminated diagnostics Director enzymes equipment ERATO eukaryotes evaluation experiments fermentation foreign funding Genentech genes genetic GILSP guidelines handling rDNA Hayashibara HEPA HEPA filters host host-vector system human International involved Japan Japanese companies Kirin Kubota Kyowa Hakko laboratory area living cells MAFF major managers manufacturing area MESC methods million Ministry MITI Mitsubishi Kasei Molecular Osaka Osaka Bioscience Institute pathogenicity percent personnel pharmaceutical companies programs projects Protein Engineering Protein Engineering Research rDNA microorganisms rDNA organisms rDNA plants recipient organism recombinant drugs recombinant organisms Research Institute RIKEN safety cabinets Science and Culture Science and Technology scientists simulated model environment strategic alliances strategy structure Suntory Takeda therapeutics Tokyo Tsukuba U.S. biotechnology U.S. companies United vaccine vector virus