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activity agents amino acid animals anti antibody antibody response antigen antigen-antibody antilymphocytic antilymphocytic serum bacteria biliary atresia biologic blood body bone marrow cellular immunity chains chemotactic chronic circulating clinical complement cytes deficiency delayed hypersensitivity demonstrated donor doses effect enzymes evidence experimental experiments function gamma globulin genetic glomerulonephritis graft guinea pig Hageman factor hepatic histamine homograft hormone host human immu immune response immunoglobulin immunologic immunosuppressive induced infection inhibition interaction interferon involved kidney laboratory lesions leukocytes liver lympho lymphoid cells lysosomes macrophages mechanisms mediators membrane ment mice molecule munologic normal organ patients phagocytosis phocytes plasma cells plasmin produce protein rabbit reaction reaginic recipient rejection release renal result role secretory sequence serum shown small lymphocytes specific SRS-A stem cells studies suggested therapy thymus tion tissue tive tolerance transfer factor transplantation tumor unresponsive vaccination viral virus viruses vitro vivo