Trends in Atherosclerosis Research (Google eBook)

Front Cover
Leon V. Clark
Nova Publishers, Jan 1, 2004 - Medical - 330 pages
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Atherosclerosis is a degenerative condition in which arteries build up deposits called plaques (atheromas) which consist of lipids (mainly cholesterol), connective tissue and smooth muscle cells originating from the arterial wall. Plaques develop quietly over a period of years and are unnoticeable until there is an interruption in the normal flow of blood. Plaques may partially or totally block the blood's flow through an artery. Two things that can happen where plaques occur are: bleeding (hemorrhage) into the plaque; and formation of a blood clot (thrombus) on the plaque's surface. Atherosclerosis affects large and medium-sized arteries. The type of artery and where the plaque develops varies with each person. Atherosclerosis research has witnessed startling progress in recent years, partially due to new drugs as well as to new breakthroughs in molecular medicine.
  

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Contents

MECHANISTIC APPROACHES TO THERAPY FOR VASCULAR INJURY
1
SURGICAL MYOCARDIAL REVASCULARIZATION OFF PUMP OR ON A BETTER PUMP?
35
TARGETING THE CD40CD40 LIGAND CD154 SYSTEM AS THERAPEUTIC INTERVENTION FOR THE TREATMENT OF ATHEROSCLEROSIS
81
THE ROLE OF MATRIX METALLOPROTEINASES IN ATHEROSCLEROTIC PLAQUE INSTABILITY
99
INVESTIGATION OF THE ROLE OF ENDOGENOUS NITRIC OXIDE SYNTHESIS IN DETERMINING PATTERNS OF ARTERIAL WALL PER...
123
LARGE ARTERY STIFFNESS STRUCTURAL AND GENETIC ASPECTS
145
SMALL VESSEL ISCHEMIC DISEASE AND ATHEROSCLEROSIS FROM PATHOPHYSIOLOGY TO RISK FACTORS
171
PATHOPHYSIOLOGY AND PATHOGENESIS OF VASCULAR COGNITIVE IMPAIRMENT A CRITICAL UPDATE
189
ASSESSMENT OF REVERSE CHOLESTEROL TRANSPORT
235
THE THERAPEUTIC POSSIBILITIES FOR THE REGRESSION OF VASCULAR CHANGES IN HYPERTENSION
261
ANALYTICAL METHODS OF ATHEROSCLEROSIS RESEARCH
279
INDEX
313
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Page 22 - Brown G, Albers JJ, Fisher LD, et al. Regression of coronary artery disease as a result of intensive lipid-lowering therapy in men with high levels of apolipoprotein B.
Page 308 - A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association.
Page 310 - Pulsatile flow and atherosclerosis in the human carotid bifurcation. Positive correlation between plaque location and low and oscillating shear stress, Atherosclerosis 5, 293-302.

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