Diagnostic Histopathology of the Bone MarrowA succinct, single-authored text and atlas of bone marrow pathology, this book is based on over 10,000 bone marrow biopsies. Divided into seven sections, it covers indications and techniques for biopsy, normal findings, and bone marrow alterations in specific neoplastic and non-neoplastic disorders and other diseases. The author approaches the practical problems and pitfalls in making particular types of diagnoses. The volume is lavishly illustrated with over 300 full-color photographs. The emphasis has been placed on the histologic interpretation of the bone marrow core biopsy, but the histopathologic findings have been integrated with clinical and laboratory features, as well as with peripheral blood and bone marrow aspiration morphology. Morphology is, in fact, accorded special attention in this book, since it remains the "gold standard" for many hematologic diagnoses and is the appropriate point of departure for more complex diagnostic investigations. More advanced immunologic and molecular techniques are not overlooked, however, and a discussion of these newer techniques is incorporated in the analysis throughout the text. Written as an introduction and guide to the interpretation of the bone marrow biopsy, this volume is intended primarily for pathologists and pathologists-in-training, but may also be used successfully by hematologists and oncologist who perform bone marrow biopsies. |
Contents
The Bone Marrow Biopsy | 3 |
The Normal Bone Marrow | 10 |
Effects of Therapy on the Bone Marrow | 20 |
Copyright | |
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Common terms and phrases
abnormalities acute granulocytic leukemia acute lymphocytic leukemia antigen aplastic anemia associated atypical basophilic blasts bone mar Bone marrow aspirate Bone marrow biopsy Bone marrow involvement Cancer carcinoma cell lymphoma cell phenotype cellular characteristic characterized chronic granulocytic leukemia chronic lymphocytic leukemia Clin Pathol Clinical and Hematologic clonal cytoplasm deficiency Differential Diagnosis diffuse distinguished eosinophilic erythroid erythropoiesis fibrosis FIGURE follicular frequently present gene Giemsa granules granulomas hairy cell leukemia Hematologic Features hematopoietic histiocytes histiocytosis Hodgkin's disease hypercellular hyperplasia immunodeficiency immunoglobulin immunophenotypic increased infiltrates iron stores Langerhans large cell lesions lymph nodes lymphadenopathy lymphoblastic lymphocytosis lymphoproliferative disorder macrophages malignant lymphoma marrow aspirate smear Marrow The bone mast cell mature megakaryocytes Megaloblastic Metastatic monoclonal morphologic myelodysplastic syndromes myeloproliferative neoplasms neutropenia neutrophils non-Hodgkin's lymphoma normal nuclei nucleoli patients plasma cell myeloma positive proliferation reactive Reed-Sternberg cells renal reticulin serum small cleaved cell small lymphocytic stain stem cells thrombocytopenia tumor virus