Basement Membranes: Cell and Molecular Biology

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Nicholas A. Kefalides, Jacques P. Borel
Gulf Professional Publishing, 2005 - Science - 428 pages
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This book brings together the most important research developments of the past 45 years that have enriched our knowledge and contributed to a better understanding of the biochemistry and cell and molecular biology of basement membranes. It describes the studies that shed light on the ultrastructural organization, the biosynthesis of the macromolecular components, their functions in embryonic development and differentiation, and in the mature state. A major portion of the book is devoted to the description of the genes that regulate the expression of the various structural macromolecules.

* Reviews the early years of research and the discovery of type IV collagen
* Presents the diversity of basement membrane morphology
* Discusses gene structure
  

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Contents

The Early Years of Basement Membrane Research
3
Introduction
19
Skin
27
The Choroid Plexus of the Brain
36
Basement Membranes in Development
43
Functions of Basement Membranes
79
Basement Membrane
115
Laminins Entactin
147
Contacts of Basement Membrane Molecules with
287
EntactinNidogen Binding to Cells
303
ImmuneMediated Diseases Involving
323
Membranous Nephropathy
333
Postinfectious Glomerulonephritis
340
Genetically Mediated and Acquired Basement
353
Diabetes Mellitus
364
Novel Biological Properties of Peptides Arising from
381

Structure and Genes
169
Minor Proteins of Basement Membranes Minor
199
Biosyntheses of Basement Membrane
225
Posttranslational Modifications
234
Internal Organization of Basement Membranes
265
Effects of Matrikines Derived from Collagens XV
394
Conclusion
400
Index
413
Copyright

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