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adipose tissue apolipoprotein atherogenic atheroma atherosclerosis B-blockers carbohydrate CHD risk cholesterol and triglycerides cholesterol concentration cholesteryl ester chylomicrons circulation clinical trials coronary disease decrease dense LDL diet dietary drugs effect elevated enzyme familial combined hyperlipidaemia fatty acids fibrates fibrous cap Figure foam cells free cholesterol HDL cholesterol hepatic heterozygotes heterozygous FH homozygotes homozygous FH hyper hypercholesterolaemia hyperlipidaemia hyperlipoproteinaemia hypertension increased LDL insulin resistance laboratory LDL cholesterol levels LDL lowering LDL receptor lesions lipid lipid-lowering liver low HDL cholesterol Lp(a mmol/litre 200 mg/dl myocardial infarction NEFA nicotinic acid NON-SMOKER normal obesity occur oxidation particularly patients with hypertriglyceridaemia phospholipids plasma polygenic polygenic hypercholesterolaemia primary prevention protein reduced renal disease risk factors secondary hyperlipidaemia secondary prevention Serum HDL cholesterol severe hypertriglyceridaemia statin therapy statins syndrome tendon xanthomata total cholesterol treatment triglyceride-rich lipoproteins triglycerides Type 2 diabetes type III hyperlipoproteinaemia vascular disease VLDL VLDL and LDL VLDL secretion xanthomata