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A new mechanism of tricyclic antidepressant action Blockade of prostaglandindependent calcium
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5-HT uptake activity administration amine amitriptyline analgesic antidepressant drugs assay assessment behaviour blood sampling brain carbamazepine chromatography clinical response clomi clomipramine clomipramine and desmethylclomipramine clomipramine and maprotiline clomipramine therapy concentrations of clomipramine correlation cortisol daily depressed patients depressive illness desipramine desmethyl dopamine dose of clomipramine effects of clomipramine endogenous depression female Horrobin imipramine increased infusion inhibition inhibitor injection International Medical Research intravenous Jones and Luscombe levels of clomipramine male Manku maprotiline mean plasma metabolism metabolite method mg clomipramine mg/kg monoamine morphine Moyes N-desmethyl metabolite ng/ml noradrenaline nortriptyline observed parent compound patients receiving pentazocine Pharmacology placebo plasma concentrations plasma levels plasma prolactin levels Postgraduate Medical Journal pramine prostaglandin antagonist prostaglandin synthesis protriptyline Psychiatry receiving clomipramine receptor REM sleep reported serum showed side effects significant slow-wave sleep stimulation Table technique therapeutic tion trial tricyclic antidepressants tryptophan Turner tyramine tyramine pressor response volunteers weeks