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Papillomaviruses

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John Wiley & Sons, Apr 30, 2008 - Science - 268 pages
A multidisciplinary volume presenting recent research relating to papillomaviruses and their association with certain types of malignant lesions. Presents up-to-date findings on their classification and their molecular biology and cell-virus interactions, including mode of entry, modification of genetic material and pathogenecity; their relationship to various kinds of skin conditions; their association with cervical carcinoma and carcinomas of the bladder and alimenatry tract, with descriptions of in vitro studies; and finally, their immunology and possible therapeutic agents, e.g., interferon and vaccination. The only comprehensive text on the subject, it brings together the work of many of the most prominent researchers in the field.
  

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Contents

Chairmans introduction
1
Classification of the papillomavirusesmapping the genome
3
Organization and expression of the genome of bovine papillomavirus type 1
23
Papillomavirus transforming functions
39
The bovine papillomavirus replicon
53
Production of spliced DNA copies of the cottontail rabbit papillomavirus genome in a retroviral vector
68
General discussion I
83
Methods for diagnosing papillomavirus inIection
86
Epidermodysplasia verruciformis a model for understanding the oncogenicity of human papillomaviruses
157
Association of human papillomavirus with squamous carcinoma of the uterine cervix
175
Persistence and expression of human papillomavirus DNA in genital cancer
190
Laryngeal papillomatosis is associated with a defect in cellular differentiation
208
Papillomaviruses and interferon
221
General discussion I1
235
Chairmans closing remarks
243
Index of contributors
247

Criteria for establishing that a virus is oncogenic
104
Papillomavirus infection in cattle viral and chemical cofactors in naturally occurring and experimentally induced tumours
117
Immunization against bovine papillomavirus infection
136

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