Growth hormone, prolactin, and IGF-1 as lymphohemopoietic cytokines
This book describes three growth and differentiation factors and their role in basic and clinical hematology and immunology: growth hormone, insulin-like growth factor 1 and prolactin. Recently, the expression of all three factors has been documented in the lympho-hemopoietic system. The relative importance of endocrine, paracrine and autocrine production is discussed. In addition to their role in development and physiology, these factors are implicated in auto-immune diseases and leukemia. Possible implications of recent findings include the use of these factors in some forms of bone-marrow aplasia and immunodeficiency. In contrast, bromocriptine (which suppresses PRL secretion) may be of value in auto-immune diseases.
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The CytokineHemopoietin Family
From Genes to Proteins
From Gene to Proteins
54 other sections not shown
Acad Sci USA activity amino acids antibodies antigen autocrine autoimmune bone marrow bromocriptine cell lines cell types chapter cytokines differentiation effect of GH Endocrinol 1993 Endocrinol Metab Endocrinology erythropoietin estrogen exon function gene expression GH and PRL GH gene GH or PRL GHRH growth hormone gene hemopoietic hPRL human growth hormone hyperprolactinemia IGF-I immune Immunol increased induced inhibition insulin insulin-like growth factor kinase lactotropes leukemia leukocytes lymphocytes lymphoid macrophages mammary gland mediated Mol Cell Mol Endocrinol molecular mouse mRNA murine mutation Natl Acad Sci ng/ml NK cells normal paracrine peripheral blood Pit-1 binding Pit-1 gene pituitary cells pituitary gland placental lactogen PRL expression PRL gene PRL levels PRLR Proc Natl Acad production prolactin gene prolactin receptor proliferation protein rat PRL regulation release response role secretion sequence serum somatostatin somatotropes spleen SRIF stimulation thymic thymocytes thymus tion tissues transcription factor tumor vitro vivo