This volume reviews selected areas of insulin pharmacology, including insulin chemistry, structure, secretion by beta cells, receptor interaction, molecular biology and cellular responses. The reviews are authoritative and up-to-date. It maintains a manageable size in spite of the extent of the subject covered, by focussing on areas that have made particularly rapid progress in recent years, and reviewing these in broad yet concise fashion.
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Chemical Synthesis of Insulin Analogs
J Larner Department of Pharmacology University of Virginia School
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abnormal insulin Acad Sci USA adipocytes affinity amino acid antibodies autophosphorylation Biochem Biophys Res Biol Chem biological activity Biophys Res Commun biosynthesis Ca2+ cAMP-dependent protein kinase casein kinase cellular cleavage COOH terminal cyclic AMP cytosolic decreased Diabetes diacylglycerol dimer effects of insulin enzyme glucagon gluconeogenesis glycogen synthase hepatocytes hepatoma cells hexamer hormone hyperpolarization identified IGF-I IGF-I receptor increase inhibition inositol insulin action insulin analogs insulin molecule insulin receptor insulin receptor kinase insulin release insulin-like growth factor insulin-stimulated intact interaction intracellular islet cells isolated Kahn CR kinase activity Malaisse WJ mediator metabolism mRNA mutant insulin Natl Acad Sci normal peptide phosphatase phosphodiesterase phospholipase phosphorylation plasma membrane polypeptide precursor Proc Natl Acad proinsulin protease protein kinase purified region regulation regulatory residues role Rubenstein AH S6 kinase secretion sequence Shoelson side chain specific Steiner DF stimulation structure studies substrate subunit sulin synthesis Tager HS tion tissue transcription tyrosine kinase vitro