Transient Receptor Potential ChannelsMd. Shahidul Islam Transient Receptor Potential Channels offers a unique blend of thoughtfully selected topics ranging from the structural biology of this fascinating group of ion channels to their emerging roles in human diseases. This single book covers TRP channels of yeasts, flies, fishes frogs and humans. And from the biophysics of primary thermo-sensory events in cells to the thermosensation at whole organism level, from physiology of pain to the development of pain-killers, from psychiatric illnesses to cancers, from skin cells to sperms, from taste buds to testes, from established facts to heated debates, this book contains something for every TRP enthusiasts, beginner and expert alike. It includes crucial background information, critical analysis of cutting edge research, and ideas and thoughts for numerous testable hypotheses. It also shows directions for future research in this highly dynamic field. It is a book readers will be just as eager to give to others as keep for themselves. |
Contents
A Therapy Target That Attracts | 637 |
Expression and Function of TRP Channels in Liver Cells | 667 |
Expression and Physiological Roles of TRP Channels | 687 |
TRPM Channels in the Vasculature | 707 |
Molecular Expression and Functional Role of Canonical | 730 |
Gene Expression | 749 |
TRP Channels in Vascular Endothelial Cells | 759 |
TRP Channels in the Cardiopulmonary Vasculature | 781 |
The TRPV5 Promoter as a Tool for Generation | 276 |
TRPP Channels and Polycystins | 287 |
TRP Channels in Yeast | 315 |
Investigations of the In Vivo Requirements of Transient | 341 |
TRP Channels in Parasites 359 | 358 |
Receptor Signaling Integration by TRP Channelsomes | 373 |
Gating Mechanisms of Canonical Transient Receptor | 390 |
Association with Orai1 | 413 |
Contribution of TRPC1 and Orai1 to Ca2+ Entry Activated | 434 |
Primary Thermosensory Events in Cells | 451 |
Biophysics of Polymodal Receptors | 469 |
Voltage Sensing in ThermoTRP Channels 517 | 516 |
TRP Channels as Mediators of Oxidative Stress | 531 |
Regulation of TRP Signalling by Ion Channel Translocation | 545 |
Emerging Roles of Canonical TRP Channels in Neuronal Function | 573 |
TRP Channels and Neural Persistent Activity | 595 |
Role of TRP Channels in Pain Sensation 615 | 614 |
41 | 784 |
107 | 791 |
173 | 799 |
TRP Channels of Islets | 811 |
Not Your | 831 |
Roles of Transient Receptor Potential Proteins TRPs | 847 |
TRP Channels in Urinary Bladder Mechanosensation | 861 |
The Role of TRP Ion Channels in Testicular Function 881 | 880 |
TRP Channels in Female Reproductive Organs and Placenta | 909 |
Oncogenic TRP Channels | 929 |
TRPV Channels in Tumor Growth and Progression | 947 |
The Role of Transient Receptor Potential Channels | 968 |
TRP Channels and Psychiatric Disorders | 987 |
Transient Receptor Potential Genes and Human Inherited Disease | 1011 |
| 1033 | |
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Common terms and phrases
Acad Sci USA acid agonists artery Bindels RJ Biochem Biol Chem Ca2+ Ca2+ channels Ca2+ entry Ca2+ influx capsaicin cation cation channel cellular channel activity domain Drosophila elegans endothelial cells epithelial expression function gating gene Genet Hoenderop JG human hyperalgesia increased induced inhibition interaction ion channels mammalian mechanism mediated Mg2+ mice modulate molecular mouse mRNA mutations Natl Acad Sci neurons Neurosci Nilius Orai1 pain pathway permeability Pharmacol phosphorylation Physiol physiological PIP2 PKD2 plasma membrane polycystic kidney disease polycystin Polycystin-1 pore Proc Natl Acad receptor potential channels regulation renal response role sensory signaling smooth muscle cells SOCE Springer Science+Business Media STIM1 stimulation structure studies subfamily temperature transient receptor potential translocation transmembrane TRP channels TRPA1 TRPC TRPC1 TRPC2 TRPC3 TRPC4 TRPC5 TRPC6 TRPM TRPM1 TRPM2 TRPM4 TRPM5 TRPM7 TRPM8 TRPML TRPP TRPP2 TRPV TRPV1 TRPV2 TRPV4 TRPV5 and TRPV6 TRPV6 vanilloid receptor vascular voltage zebrafish