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agent Key functional alcohol Alkene Alkyl Aryl Benzyl biotransformation pathway carboxylic acid Chem comparison with reference cytochrome P-450 derivative detected dialkyl Dispos dog oral dose was excreted drug Key functional Drug Metab enantiomer enzyme ester ether excreted in urine extracted FAB-MS faeces formation formed GC-MS glucuronide glucuronide conjugate glutathione glutathione conjugates H NMR hepatocytes HPLC human liver microsomes hydrolysis hydroxylation incubation inhibitor intravenous investigated isolated isomer ketone Key functional groups liver liver microsomes Structure liver slices main metabolites major component major metabolite male rats mercapturic acid metabolism metabolites metabolites were identified methyl mg kg mg kg"1 mice microsomes N-oxide NHCOCH3 oral administration oral dose oxidation phenol plasma rabbit Radioactive components rat liver microsomes Rat oral rat urine separated by HPLC species stereoselective Structure and biotransformation sulfate conjugate sulfonic sulfonic acid sulfoxide Test system Toxicol urinary metabolites urinary radioactivity urine and faeces Use/occurrence vitro vivo Xenobiotica