Stem Cells: From Bench to Bedside

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Ariff Bongso, Eng Hin Lee
World Scientific, Jan 1, 2005 - Science - 565 pages
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Stem cell biology has gained tremendous interest in the recent years, driven by the hope of finding cures for several diseases through transplantation medicine. Various types of stem cells have been identified from preimplantation embryos, the fetus, placenta and adult. The isolation of human embryonic stem cells has been considered the biggest breakthrough of the 21st century. Some of these stem cell types are charged with ethical controversies although they are versatile and offer tremendous potential for finding cures for incurable diseases. In fact, cures for diabetes, heart diseases, Parkinson's, Alzheimer's, and many other diseases via stem cell research is expected within the next 10 years. The documentation of the latest information on these various stem cell types is compartmentalized in different journals and texts. This book brings together the state-of-the-art on all the types of stem cells, written by giants in the respective fields. It is hoped that knowledge of one stem cell type will complement the other and much can be learned by interaction. This book is aimed at undergraduates, postgraduates, scientists, embryologists, tissue engineers, doctors and biomedical scientists with an interest in stem cell research. It is different from other texts in that it is very comprehensive, covering all aspects of stem cells. Additionally, all the various chapters are written by renowned scientists in the specific fields. The topics are uniquely treated in that they cover research at the laboratory bench as well as the clinical applications. Many of the chapters carry extensive self-explanatory figures, colored photographs, graphics and tables. Both the editors are also renowned in the stem cell field, and both come from medical disciplines and are senior university academics with excellent track records.
  

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Contents

Their Definition Classification and Sources Ariff Bongso and Eng Hin Lee
1
Blastocyst Culture Xenofree Derivation and Cryopreservation Properties and Applications of Embryonic Stem Cells Ariff Bongso Mark Richards and ...
14
Chapter 3 Characterization of Human Embryonic Stem Cells Maryam M Matin Ahmad Bahrami Duncan Liew and Peter W Andrews
38
Chapter 4 Stem Cells and Their Developmental Potential Martin F Pera and Mirella Dottori
55
Chapter 5 Transcriptome Profiling of Embryonic Stem Cells Mahendra Rao and Bing Lim
71
Chapter 6 Culture Subcloning Spontaneous and Controlled Differentiation of Human Embryonic Stem Cells Michal Amit Sharon GerechtNir and Jos...
98
Chapter 7 Differentiation In Vivo and In Vitro of Human Embryonic Stem Cells Barak Blum and Nissim Benvenisty
123
Chapter 8 Feederfree Culture of Human Embryonic Stem Cells Scott A Noggle Noboru Sato and Ali H Brivanlou
144
Chapter 15 Differentiation of Human Embryonic Stem Cells to Cardiomyocytes Chris Denning Robert Passier and Christine Mummery
301
Chapter 16 Differentiation of Human Embryonic Fetal and Adult Stem Cells to Islet Cells of the Pancreas Enrique Roche and Bernat Soria
325
Chapter 17 Progress in Islet Transplantation AM James Shapiro and Sulaiman Nanji
345
Chapter 18 Differentiating Human Stem Cells to Neurons SuChun Zhang
367
Chapter 19 Liver Stem Cells Malcolm R Alison Pamela Vig Francesco Russo Eunice Amofah and Stuart J Forbes
389
Chapter 20 Stem Cells of the Eye Leonard P K Ang and Donald T H Tan
420
Chapter 21 Bone Repair and Adult Stem Cells Dietmar Werner Hutmacher and Suman Lal Chirammal Sugunan
442
Chapter 22 Stem Cells and Cartilage JB Richardson JTK Lim JHP Hui and EH Lee
466

Chapter 9 Epigenesis in Pluripotent Cells Lisa M Hoffman Jennifer Batten and Melissa K Carpenter
161
Chapter 10 Stem Cells and Translational Medicine Ethics Law and Policy Justine Burley
186
Derivation and Propagation of Human Embryonic Stem Cells by Somatic Cell Nuclear Transfer Woo Suk Hwang Byeong Chun Lee Sung Keun Kan...
212
Chapter 12 Hurdles to Improving the Efficiency of Therapeutic Cloning Christopher S Navara Calvin Simerly SangHwan Hyun and Gerald Schatten
237
Basic Science to Clinical Applications Daniel L Kraft and Irving LWeissman
253
Chapter 14 Hematopoietic Stem Cells for Leukemias and other Life Threatening Hematological Disorders Patrick Tan
293
Chapter 23 Ligament and Tendon Repair with Adult Stem Cells James Cho Hong Goh and Hong Wei Ouyang
497
Chapter 24 Germ Cell Differentiation from Embryonic Stem Cells Mark Richards and Ariff Bongso
510
Their Outcome and Possible Benefits in Humans F Fandrich and M Ruhnke
523
Chapter 26 The Challenges of Cellbased Therapy Sir Roy Calne
544
Index
561
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