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Acta Psychiatr Scand Acta Psychiatrica Scandinavica age of onset Agoraphobia amygdala antidepressant anxiety and depression anxiety and mood anxiety disorder GAD anxiety disorders anxiolytic assessed associated with pure baseline buspirone clinical comorbid anxiety comorbid GAD corticotropin-releasing factor criteria Denmark depressive disorders dexamethasone DSM-III DSM-III-R DSM-IV dysregulation effects epidemiological evaluate fluoxetine follow-up GAD and MDE GAD without MDE GAD-MDE HAM-A total score help-seeking hippocampal HPA axis increased independent disorder Kessler RC M-CIDI manuscript MDE without GAD mental disorders mood disorders Munksgaard 2000 Munksgaard International Publishers National Comorbidity Survey odds ratios onset of depression panic disorder placebo Psychiatr Scand 2000 psychic anxiety factor pure and comorbid pure anxiety pure depression pure GAD pure MDE response reviewed risk factors Risskov samples severity marker significant significantly SNRIs social phobia specific phobia SSRIs studies superior to placebo symptoms temporally primary upregulation venlafaxine XR vulnerability and risk week Wittchen Wyeth-Ayerst