Protein Structure, Stability, and Folding (Google eBook)

Front Cover
Kenneth P. Murphy
Springer Science & Business Media, 2001 - Science - 264 pages
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With the huge increase in available data on the DNA sequences of proteins, there is a growing need to understand and characterize how proteins fold into their biologically active native states and the basis for the stability of these states. In Protein Structure, Stability, and Folding, Kenneth P. Murphy and a panel of internationally recognized investigators describe some of the newest experimental and theoretical methods for investigating these critical events and processes. Among the techniques discussed are the many methods for calculating aspects of protein stability and dynamics from knowledge of the structure, for calculating conformational entropy, and for performing molecular dynamics simulations of protein unfolding. New experimental approaches presented include the use of co-solvents, novel applications of hydrogen exchange techniques, temperature-jump methods for looking at folding events, and new strategies for mutagenesis experiments. Unique in its powerful combination of theory and practice, Protein Structure, Stability, and Folding offers protein and biophysical chemists the means to gain a more comprehensive understanding of this complex area by detailing many of the major innovative techniques in use today.
  

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Contents

Stabilization of Protein Structure
1
Protein Stabilization by Naturally Occurring Osmolytes
17
The Thermodynamic Linkage Between Protein Structure Stability and Function
37
Measuring the Conformational Stability of a Protein by Hydrogen Exchange
69
Modeling the Native State Ensemble
93
Conformational Entropy in Protein Folding
117
Turn Scanning
133
Laser TemperatureJump Methods for Studying Folding Dynamics
159
Kinetics of Conformational Fluctuations by EX1 Hydrogen Exchange in Native Proteins
193
Molecular Dynamics Simulations of Protein UnfoldingFolding
215
Index
249
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