Applied physiology in respiratory mechanics
The publication deals with the management of critically ill patients, in which the use of sophisticated respiratory function monitoring and support equipment stresses the need to deeply analyse various aspects of respiratory physiology. There are mechanisms of ventilation setting, muscular fatigue, static and dynamic properties of the respiratory system, respiratory work, gas exchange and pulmonary perfusion. Advanced research on techniques supplying partial support to ventilation and applied pharmacology benefit from a better understanding of the factors and mechanisms regulating the respiratory function. It is therefore fundamental to stress the relevance for ICU physicians to plan a clinical approach increasingly oriented towards a customized ventilatory support, relying on applied reseach.
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Respiratory muscle function
Respiratory muscle dysfunction
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acute respiratory failure airflow airway pressure airway resistance alveolar pressure alveoli Appl Physiol arterial assessment Auto-PEEP Bates JHT behaviour capnography changes chest wall chronic obstructive pulmonary clinical cm H2O compliance constant COPD patients CPAP cycle decrease deflation diaphragm diaphragmatic dynamic edema effect elastic end-expiratory endotracheal tube esophageal pressure expiration expiratory flow flow-triggering force frequency function gas exchange hypercapnia hyperinflation hypervolaemia hysteresis increase inflation inspiration inspiratory effort inspiratory flow linear load lung and chest lung mechanics lung parenchyma lung tissue lung volume Macklem PT measured mechanical ventilation mechanically ventilated patients Milic-Emili minute ventilation monary neural drive normal subjects obstructive pulmonary disease occlusion output oxygen PaCO2 PaO2 parenchyma PCO2 PEEP PEEPi PetCO2 phrenic nerve Po.i pressure-volume pulmonary edema respiratory drive respiratory mechanics respiratory muscle fatigue respiratory system Rev Respir SIMV spontaneous breathing static surfactant technique tidal volume tion values venous ventilatory failure viscoelastic weaning from mechanical