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ACLM anti anti-factor Ha activity anti-factor Xa anti-Ila anticoagulant antithrombin III antithrombotic arterial bioavailability bleeding bypass Ca-heparin coagulation compared controlled trials daily injections dalteparin deep venous thrombosis deep-vein thrombosis disease dosage dose drug efficacy and safety enoxa enoxaparin enoxaparin group factor Xa Fragmin GAGs Haemostasis half-life hepa heparin group heparin prophylaxis Hirsh incidence of DVT inhibition intravenous IU anti-Xa Karger lecular LMW heparins LMWHs low mo low molecular weight low-molecular-weight heparins medical patients ment mg enoxaparin ml/min molecular weight heparin myocardial infarction nadroparin parin parnaparin patients undergoing pharmacokinetic pharmacological placebo platelet postoperative Prof prophylaxis pulmonary embolism randomised randomized ratio renal risk factors risk of thrombosis Samama standard heparin subcutaneous surgery Table therapeutic therapy Thromb Haemost Thromb Res thrombin thromboembolic events thromboembolic risk tients tinzaparin tion total body clearance treatment of deep unfractionated heparin vascular vein thrombosis venous thromboembolism vention