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abnormalities acute attacks analgesic ankylosing spondylitis Ann Int Ann Rheum anti-inflammatory agents antigen antinuclear antibody arteritis Arthritis Rheum aspirin associated back pain biopsy blood cell count bone calcium cervical spine characterized chronic clinical colitis common connective tissue diseases corticosteroids cutaneous daily degenerative joint disease disorders dose drug effective erythrocyte sedimentation rate evaluation fever frequently gout hematocrit inflammation inflammatory injection intra-articular involved joint symptoms knee laboratory studies lesions low back manifestations medial mg QID mild muscle negative nerve normal noted occur onset osteoporosis patients physical examination polyarthritis polymyalgia rheumatica polymyositis prednisone protein pseudogout psoriatic psoriatic arthritis pulmonary rash Raynaud's phenomenon Reiter's syndrome relief renal response revealed rheumatic rheumatoid arthritis rheumatoid factor Roentgenograms salicylates scleroderma seen serum uric acid severe skin steroid steroid therapy swelling synovial fluid systemic lupus erythematosus temporal tenderness tendon therapeutic tion toxicity trauma treatment ulcerative uric acid urinalysis usually vasculitis white blood cell wrist