Altered Fates: Gene Therapy and the Retooling of Human Life

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W. W. Norton & Company, 1996 - Medical - 592 pages
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As gripping as a novel, this tale of science, medicine, politics, and the jealousies, passions, and dedication of the human heart is certain to be recognized as one of the major nonfiction works of the decade. Seven years in the making, Altered Fates chronicles the saga of gene therapy, a medical revolution unparalleled in human history. Scientists armed with powerful new tools of genetic engineering are attacking such deadly disorders as lung cancer, heart disease, and AIDS by repairing and replacing defective genes. Further, they are racing to find the genes responsible for depression, schizophrenia, Alzheimer's disease, and other psychiatric and neurologic disorders, and they are consummating the marriage of genetics and reproductive technology, raising the possibility of human cloning and the production of "designer" babies. In the pages of this rich and detailed narrative, whose characters include the field's leading scientists as well as key patients and their families, the Pulitzer Prize-winning authors tell the story of the race to be the first to do gene therapy (a feat almost certain to garner a Nobel Prize and a place in medical history), uncovering the behind-the-scenes machinations and rivalries among the prima-donna researchers at some of the world's leading medical centers, including the National Institutes of Health. They also reveal the details of the initial human experiments in gene transfer, and the agonizing decisions faced by the families of the first children to be submitted to the therapy.
  

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Altered fates: gene therapy and the retooling of human life

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Chicago Tribune reporters Lyon and Gorner revisit their Pulitzer Prize-winning series on genetic research and therapy in this absorbing look at arguably the most important developments in the history ... Read full review

Contents

Introduction
9
PART
15
A Gathering of Geese
17
The Long and Winding Road
38
A Simple Little System
59
The Horror
86
The Understudy Steps In
105
The Road Forks
120
Aftermath
277
A Matter of the Heart
299
Jekyll and Hyde
322
Triumph or Tragedy?
349
The Thief of Breath
383
It Takes a Worried Man
407
Delivering the Goods
428
Something in the Blood
457

The Troika Forms
138
Gene Transfer Is Born
162
Gene Therapy Meets the Public
176
Victory
202
September 14 1990
227
One Errant Cell
241
Belt and Suspenders
259
Gypsy Fortunetellers of Technology
480
The Ultimate Frontier
507
Prophecy
531
Acknowledgments
569
Index
613
Copyright

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Page 590 - Genetic analysis of an inherited predisposition to colon cancer in a family with a variable number of adenomatous polyps.

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About the author (1996)

Jeff Lyon and Peter Gorner, recipients of the Pulitzer Prize for Journalism in 1987 for the stories on which Altered Fates was based, write for the Chicago Tribune. They live in Chicago.

Jeff Lyon and Peter Gorner, recipients of the Pulitzer Prize for Journalism in 1987 for the stories on which Altered Fates was based, write for the Chicago Tribune. They live in Chicago.

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