Pharmaceutical capsules

Fridrun Podczeck, Brian E.. Jones

Pharmaceutical Press, 2004 - Medical - 272 pages

Previously published as Hard Capsules, this updated and expanded second edition covers all aspects of capsule technology, including history, standards, methods and equipment used in manufacture, filling, printing, weighing, cleaning and inspecting of both hard and soft capsules. Pharmaceutical Capsules is an essential resource for all those involved in the development, manufacture and testing of capsules. It will also be valuable to pharmaceutical science students and regulatory authorities.

Contents

• Developments in the use of onepiece gelatin capsules: 8
• manufacture and physicochemical properties: 23
• Chilling and drying: 36
• Gelatin alternatives and additives: 61
• Manufacture and properties of twopiece hard capsules: 79
• Quality control: 89
• References: 98
• Powder flow and packing properties: 104
• Filling of granules and pellets 1 15: 115
• Dry filling of hard capsules 1 19: 119
• Indirect filling methods for powders and granules: 125
• Filling of pellets: 132
• Instrumented capsulefilling machines and simulators 139: 140
• The simulation of capsulefilling equipment: 148
• Capsule processing and packing: 157
• Thermoforming machines: 163
• Filling of liquids and semisolids into hard twopiece capsules: 169
• Capsulefilling technology: 178
• Drug delivery: 184
• Alternatives to gelatin for twopiece capsules: 191
• Technology to manufacture soft capsules: 195
• Formulation and physical properties of soft capsules: 201
• Drug release from capsules: 213
• Capsule standards: 239

Bibliographic information

• Title: Pharmaceutical capsules
• Editors: Fridrun Podczeck, Brian E.. Jones
• Edition: 2, illustrated
• Publisher: Pharmaceutical Press, 2004
• ISBN: 0853695687, 9780853695684
• Length: 272 pages
• Subjects: Medical / Pharmacy