Polyunsaturated fatty acids in human nutrition
This volume highlights the important clinical implications of recent findings on the biochemistry, metabolism, and physiological functions of long chain polyunsaturated fatty acids (LCPUFAs). Leading experts define the relationships between dietary LCPUFAs and their structural-metabolic physiological role, examine the influence of LCPUFAs and other essential fatty acids on infant development, discuss the evidence linking various disorders to essential fatty acid imbalance, and describe new approaches to problems relating to dietary LCPUFAs, particularly in infant feeding.
The contributors review the most significant research on the transport and cellular utilization of LCPUFAs, their role in phospholipid molecular species, their extracellular and intracellular fates, their metabolism to oxidative derivatives, and their functions as mediators - through eicosanoid-dependent and/or independent mechanisms - brain and retinal development, immunomodulation, and other physiological processes. Extensive studies explore the relationship between essential fatty acid balance and cystic fibrosis, behavior problems, chronic diseases, atopic dermatitis, gynecological and reproductive disorders, and disturbances of lipoprotein metabolism. Full consideration is given to the intake, digestion, absorption, and metabolism of LCPUFAs in newborn infants and the special problems of premature infants and infants with peroxisomal disorders. Practical issues concerning sources and uses of dietary LCPUFAs are also discussed in detail.
Polyunsaturated Fatty Acids in Human Nutrition is an essential source of information for nutritionists, pediatricians, and clinicians treating disorders involving fatty acid imbalance. The book will also be a valuable stimulus for basic researchers investigating the role of fatty acids in human biology.
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Past and Future
Long Chain Fatty Acid Metabolism
Physical Properties of Fatty Acids and their Extracellular
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acid metabolism activity acylation albumin arachidonic acid babies Bazan bile binding Biochem Biol Chem Bracco brain chain fatty acids cholesterol Clin concentrations cystic fibrosis Deckelbaum desaturation diacylglycerol diet disease disorders docosahexaenoic acid double negative thymocytes eicosanoid eicosapentaenoic acid enzyme essential fatty acid esters fatty acid composition fetal fish oil formula function hormone human milk increase intake Koletzko LCPUFA Leukotrienes levels linoleic acid linolenic lipase Lipid Res lipids lipoproteins lipoxygenase liver long chain fatty long chain polyunsaturated low birthweight LTB4 mechanisms membrane lipids microsomes n-3 fatty acids neonatal Nutr Nutrition oxidation pathway patients Pediatr peroxisomal phosphoglycerides phospholipids photoreceptor cells physiological plasma platelets polyunsaturated fatty acids premature infants prostaglandins protein kinase PUFA ratio receptor retina role saturated serum Spector AA sphingosine studies substrate synthesis thymocytes tissues triglyceride unsaturated fatty acids uptake VLCFA Zellweger syndrome